HYPOTENSIVE AGENTS: AN ANIMAL MODEL

Hypotensive Agents

Smooth muscle contraction differs somewhat from skeletal muscle. Ca is involved in the initiation of contraction as it is in skeletal muscle. However, the myosin in smooth muscle must be phosphorylated for activation of the myosin ATPase. Phosphorylation and dephosphorylation of myosin also occurs in skeletal muscle, but phosphorylation is not necessary for activation of the ATPase. In smooth m...

Ocular Hypotensive Agents

β-BLOCKERS Currently, this class includes non-selective (timolol, levobunolol, metipranolol, carteolol) and β1specific (betaxolol) agents. How blockade of the β-receptors of the ciliary body (CB) epithelium leads to ocular hypotensive effects of these drugs is not known. It is suspected that the tonic sympathetic stimulation, provided by norepinephrine, is inhibited through β-blockade, resultin...

Hypotensive agents and techniques.

MAKING AN EXPERIMENTAL ANIMAL MODEL FOR MULTIPLE SCLEROSIS

To understand the mechanism of Multiple Sclerosis (MS), an autoimmune demyelinating disease, the researchers developed an experimental animal model for MS, which is called EAE (Experimental Allergic Encephalomyelitis). There are several methods for inducing this animal model. In this research the active EAE, which is developed by injecting bovine myelin antigens into genetically susceptibl...

Cerebral atheroembolism. An animal model.

Human atheromatous material was injected into the cerebral vasculature of anaesthetized rabbits via the left common carotid artery. The lethality of varying dosages was determined and the distribution and general character of occlusive vascular lesions which developed were analyzed by light and transmission electron microscopy. It was found that a dose exceeding 55 mg of the atheromatous materi...